Introducing PBMC-LT Platform: Revolutionizing Immunotherapy Research

Say goodbye to the limitations posed by Graft-versus-Host Disease (GVHD) in PBMC models! The PBMC-LT Platform is here to reshape the landscape of research, offering a breakthrough solution that overcomes the GVHD challenge. GVHD has long been a hindrance in PBMC models, as human immune cells within the PBMC trigger xenogeneic rejection in mice, resulting in skin, intestinal, and hematological damage, and often culminating in fatality.

Leveraging MHC-Deficient Mouse Models: Our secret weapon against GVHD. By utilizing mice lacking MHC molecules, we've managed to prevent the presentation of mouse antigens to human PBMC, effectively circumventing the occurrence of GVHD. With a solid foundation of robust and stable PBMC reconstruction capabilities, Créatif Bioscience has tackled the hurdles of inadequate activation and reconstruction challenges that were previously faced with PBMC models. We've achieved successful human immune system reconstruction in B2M-NDG mice, marking a significant stride towards overcoming the GVHD drawback in PBMC models.

Key Advantages:

Stable PBMC Reconstruction: Our platform excels in reliable PBMC reconstruction, providing a consistent and dependable research environment.

GVHD-Free Treatment Periods: Bid farewell to the specter of GVHD during drug administration, ensuring unobstructed and accurate assessments of drug efficacy.

Elevated Animal Well-being: Compounds inducing acute GVHD in humanized mice with PBMC-immune systems have drastically reduced impacts on animal health within this model, offering an elevated level of safety.

Reconstructing NK Cells: Fortifying Immune Potential: Our platform not only tackles GVHD, but also boasts the capability of robustly reconstructing NK cells, broadening the horizons of your research endeavors.

Choose PBMC-LT Platform and Embark on a Trailblazing Immunotherapy Journey:

Wave goodbye to GVHD limitations and usher in a new chapter of transformative research. Through MHC-deficient mouse models, our platform clears the path for true breakthroughs. With steadfast reconstruction and GVHD prevention, your research potential knows no bounds. Contact us now to unlock the boundless potential of the PBMC-LT Platform, and elevate your research to unparalleled heights.

Case 1. B2m-NDG

Case 2. B2m-hIL15

Case3 DKO-NCG

Case4 DKO-NCG