Immunocompetent mice, endowed with a natural immune system, play an irreplaceable role in the evaluation of vaccine efficacy and immune response for pharmaceuticals. At Création Modèle Biotech, our proficiency in animal handling enables us to employ diverse immunization techniques for vaccines or antigens. Leveraging advanced methods such as ELISpot and flow cytometry, we accurately assess the generation of specific cytotoxic T lymphocytes (CTLs). This precision allows us to distinguish the cellular immune activation capabilities of different vaccines. Trust us for comprehensive and accurate evaluations, driven by our expertise in immunological assessments using immunocompetent mouse models.

Platform Features and Applications:
●    Screen vaccine sequences
●    Screening antigen peptide sequences
●    Screening adjuvants
●    Testing optimized vaccine dosing regimens
●    In vivo drug efficacy experiments

Case1
After intramuscular injection of tumor vaccine, mouse immune cells can be activated by stimulators. However, mouse immune cells after immunization with empty vector, pure antigen and adjuvant cannot be activated by activators to produce CTL . At the same time, in the tumor vaccine immunization group, DC cells also increased significantly after the mouse immune cells were activated by stimulants.
 

Case2  2 
After immunizing mice with different tumor vaccines, the vaccine sequences are screened by detecting the activation of the vaccines by different antigenic peptides.

Case 3
Mice were immunized with the mRNA vaccine , and the expression of the reporter gene in the mice was observed 6h-24h after vaccination.