Humanized MHC Immunocompetent Mouse Model
Elevate Your Research with a Comprehensive Humanized TAP/MHC Antigen Presentation System in Mice!
The TAP/MHC antigen presentation system is wholly humanized, propelling antigen presentation to new heights.
Key Advantages:
● Enhanced Antigen Presentation: This model excels in presenting antigens effectively, ensuring optimal immune responses.
● High-Affinity TCRs: Harness high-affinity T-cell receptors (TCRs) that bind strongly to antigens, enhancing your research capabilities.
● Dual Humanization of TAP: The advantage lies in the humanization of both MHC molecules and TAP molecules. Humanized TAP molecules optimize antigen peptide recognition by selectively binding hydrophobic, basic, and aromatic amino acid sequences.

Mouse TAP: Binds to peptide sequences with hydrophobic C-terminal amino acids.
Human TAP: Preferentially binds to peptide sequences with basic/aromatic/hydrophobic C-terminal amino acids.
●Diverse Antigen Delivery: Unlock the potential to present diverse antigens, including peptides, proteins (RNA, DNA), and more, while accurately screening naturally processed epitopes.
● Robust Epitope Selection: Experience unparalleled epitope screening proficiency, backed by high efficiency and accuracy.
Applications:
● Cancer Vaccines: Validate the accuracy and efficacy of candidate vaccines for tumors, ensuring precision in immunotherapy.
● Viral Epitope Mapping: Uncover the complete landscape of various viruses (HBC/HPV/EBC/CMV/ERV...) with unmatched accuracy.
● Tumor-Specific Markers: Identify and validate tumor-specific markers, offering a cornerstone for both wet-lab and bioinformatics-driven research.
● Novel Antigen Discovery: Identify novel tumor antigens, providing invaluable data for both wet-lab screenings and bioinformatics analyses.
● TCR Screening and Validation: Utilize this model for TCR refinement and validation, improving immune response studies.
Case study.

TAP/MHC Antigen Presentation System Fully Humanized High Antigen Presentation Efficiency Access to High-Affinity TCRs