Key words: BAF3 genetically engineered cell line, allograft model, efficacy experiment

　　BAF3 engineered cell lines based on Casper Cas9 technology can provide pharmacodynamic experimental models with a variety of resistance mutations that are rare in conventional CDX and PDX models. The model biology is based on NIG mice that are more tolerant to BAF3 engineered cell lines. A stable and reliable efficacy test platform of BAF3 engineering cell line in vivo was established.

　　• BA/F3 engineered cell lines depend on IL-3 proliferation and insert overexpressed mutant Driver genes. It is an ideal experimental system for targeted drug development.

　　Based on the tolerance of NPSG mice to immunotoxicity, successfully transplanted BA/F3 engineered cell lines covering a variety of hot, rare, and drug-resistant targets into in vivo models.

　　• Stable tumor growth and strong reproducibility.

　　• The efficacy of various inhibitors is consistent with literature reports.

　　The platform is suitable for:

　　• PK/PD experiments to find the optimal dose in vivo

　　• Screening of alternative compounds while determining efficacy and toxicity

　　• Easy access to a comparison of the efficacy of previous generation inhibitors for IND application trials.

　　There are abundant BAF3 engineered cell lines in the model organisms, and the targets involve NTRK, RET, MET, EGFR, HER2 and other key genes and a variety of mutation types. See BAF3 engineering cell line list for details

　　Contact us, our biological science support department will give you a detailed introduction of our experimental platform, we will assist you to choose the appropriate model for new drug development, and give you suggestions on experimental design based on our experience in tumor models. Follow us for professional tumor model support.