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InnoModels Biotechnology: What are the unique advantages of a humanized model of the immune system?

  • Categories:Company news
  • Author:InnoModels
  • Origin:InnoModels
  • Time of issue:2024-03-22 10:34
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(Summary description)With the continuous progress of science and technology, mankind's understanding of living organisms has gradually deepened. In the medical field, in order to better simulate the human environment for disease research and drug screening, scientists have developed humanized models. The humanized model of immune system of InnoModels Biotechnology, with its unique advantages, has brought a new dawn for medical research

InnoModels Biotechnology: What are the unique advantages of a humanized model of the immune system?

(Summary description)With the continuous progress of science and technology, mankind's understanding of living organisms has gradually deepened. In the medical field, in order to better simulate the human environment for disease research and drug screening, scientists have developed humanized models. The humanized model of immune system of InnoModels Biotechnology, with its unique advantages, has brought a new dawn for medical research

  • Categories:Company news
  • Author:InnoModels
  • Origin:InnoModels
  • Time of issue:2024-03-22 10:34
  • Views:
Information

With the continuous progress of science and technology, mankind's understanding of living organisms has gradually deepened. In the medical field, in order to better simulate the human environment for disease research and drug screening, scientists have developed humanized models. The humanized model of immune system of InnoModels Biotechnology, with its unique advantages, has brought a new dawn for medical research.
I. High Stability: Stable Reconstruction of Immune System
Traditional immune system models often face stability problems, and the reproducibility of experimental results is not strong, resulting in scientific research being hindered. However, the humanized model of the immune system of InnoModels Biotechnology has successfully solved this problem by virtue of its high stability. After improvement, the success rate of experimental modeling has increased from the original 50% to an amazing 87%. This means that researchers can have more confidence in the reliability of the experimental results and conduct in-depth investigations on the basis of using the model of InnoModels.
In addition to the increase in modeling success rate, the stability of the model from InnoModels Biotechnology is also reflected in the significant reduction of the within-group coefficient of variation. The intra-group coefficient of variation is an important indicator of the consistency of experimental results, and the lower its value, the less fluctuation of experimental results and the more stable they are. After optimization, the within-group coefficient of variation of the model has been drastically reduced from the original 120% to 20%, providing more reliable experimental data for researchers.

 


Multi-cell reconstruction: industry-leading all-round simulation
The immune system is a complex network involving the interaction of multiple immune cells. In order to more realistically simulate the human immune system, InnoModels' model realizes multi-cell reconstruction. This includes a variety of immune cells such as T-cells, B-cells, NK-cells, macrophages, DC-cells and so on. Each cell plays its unique role in the model, and together they form a complete immune system network.
Through multicellular reconstruction, the model from InnoModels Biotechnology is able to more comprehensively simulate the responses and changes of the human immune system. Researchers can use these models to study the interactions between different cells, investigate the mechanisms of disease onset and progression, and evaluate the effects of drugs on the immune system. This all-encompassing simulation capability makes InnoModels' models a leader in the industry.
III. Close to Human Concentration: Providing a Realistic Environment for Drug Testing
Drug testing is an important part of medical research, and its results are directly related to the safety and effectiveness of drugs. In order to more accurately assess the effects of drugs, a testing platform close to the real environment of the human body is needed. The humanized model of the immune system of InnoModels Biotechnology meets this need.
The reconstructed number of immune cells in the model can reach or approach the concentration of human immune cells, providing a more realistic environment for drug testing. This means that researchers can simulate the metabolism and action process of drugs in the human body in the model, and predict the effects of drugs on the immune system, so as to screen for safer and more effective drugs.
In summary, the humanized model of the immune system by InnoModels Biotechnology has brought new breakthroughs in medical research with its advantages of high stability, multi-cell reconstruction and close concentration to the human body. With the continuous improvement and application of this model, it is believed that future medical research will be more in-depth, precise and efficient.

Keyword:

In the vast field of oncology and tumor immunopharmacodynamics research, InnoModels Biotechnology (Beijing) Ltd. has become a leader in the industry with its outstanding innovation ability and profound scientific research background. This company, co-founded by scientists from Novo Nordisk China R&D Center, Sino-US Crown and Shanghai Jiao Tong University Institute of Immunology, has been committed to building a stable domestic platform of humanized mouse models of the immune system (HIS) and human tumor xenografts (PDX) since its establishment in 2020, to provide new drug discovery and development companies, translational medicine researchers, and tumor patients with new-generation laboratory animal models for new drug discovery companies, translational medicine researchers, and tumor patients
In recent years, many breakthroughs have been made in the field of biomedical research, among which iHuPBMC-T technology is undoubtedly a shining star. As an innovative platform built by InnoModels Biotechnology (Beijing) Co., Ltd, iHuPBMC-T, with its unique technological advantages, shows great potential in optimizing the reconstruction of human peripheral blood single nucleated cell (PBMC) model and immuno-oncology research.
Recently, InnoModels Biotechnology (Beijing) Co., Ltd. has made a major breakthrough in the field of pharmaceutical technology, and successfully obtained a patent entitled “Method and application for the detection of immune system rebuilding ability of PBMC”. This patent not only adds a new footnote to the R&D strength of InnoModels Biotechnology in the field of biomedicine, but also provides a strong technical support for the promotion of drug research and development and the establishment of humanized experimental animal models
With the rapid development of biotechnology, the in-depth study of the immune system has become the key to new drug discovery, disease diagnosis and treatment. InnoModels Bio-technology (Beijing) Co., Ltd. provides strong support for researchers with its profound scientific background and advanced technology platform. Among them, the ELISpot platform of InnoModels Biotechnology has made a name for itself in the field of immunology research with its high sensitivity and multi-functionality
InnoModels' ADCC platform plays a pivotal role in advancing cancer treatment, and its unique technological advantages and innovative concepts have brought about a far-reaching impact on the field of tumor immunotherapy. The following is a detailed introduction of how the platform promotes the advancement of cancer treatment
In the field of tumor immunotherapy, complement-dependent cytotoxicity (CDC), as an important therapeutic mechanism, is gradually showing its great potential and value. In order to explore this mechanism more deeply, with its profound accumulation in the field of oncology and tumor immunopharmacodynamics CRO services, InnoModels Biotechnology (Beijing) Co., Ltd. has launched the CDC in vitro immune-tumor cell co-culture killing experimental platform, which provides researchers with a powerful and precise tool to help innovate cancer treatment
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InnoModels Biotechnology (Beijing) Co., Ltd.

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