In the current field of biomedical research, tumor immunotherapy is undoubtedly one of the most promising therapeutic means. Among them, antibody-dependent cytotoxicity (ADCC), as an important immune mechanism, plays a pivotal role in tumor treatment. The ADCC platform built by InnoModels Biotechnology is based on this mechanism and provides powerful in vitro experimental support for tumor immunotherapy research.
1、ADCC mechanism and tumor immunotherapy
ADCC is an antibody-mediated immune cell killing mechanism. When antibodies bind to antigens on the surface of tumor cells, these antibodies can bind to Fc receptors on the surface of immune cells (e.g., natural killer cells, NK cells), thereby activating these immune cells and causing them to attack tumor cells. In this process, NK cells, as key players, are responsible for attacking those tumor cells labeled by antibodies.

2. Characteristics of InnoModels Biotechnology ADCC platform
(1) Diversity of target cell choices: InnoModels' ADCC platform provides a variety of target cell choices, including tumor cell lines, primary tumor cells and genetically engineered cell lines. These target cell choices not only meet a wide range of research and testing needs, but also more realistically simulate the biological environment, providing closer to real experimental conditions for tumor immunotherapy research.
2) Abundance of effector cell sources: The platform also demonstrates its flexibility in the selection of effector cells. In addition to commercially available PBMC (peripheral blood mononuclear cells), there are also clinical patient-derived PBMC and the NK92 cell line, which is specifically designed for NK cell research. These diverse sources of effector cells allow researchers to choose the most appropriate cell type for specific research needs.
3) High-precision detection and analysis tools: The platform uses high-precision technologies such as flow assay, which can accurately distinguish between effector cells and target cells, providing accurate data support for research. At the same time, through flow technology, it can also accurately calculate the proportion of apoptotic cells, so as to intuitively assess the effect of ADCC.
3、Significance of the ADCC platform of InnoModels Biotechnology
InnoModels' ADCC platform not only provides powerful in vitro experimental support for tumor immunotherapy research, but also promotes the research progress in this field. Through this platform, researchers can gain a deeper understanding of the role of ADCC mechanism in tumor immunotherapy and provide theoretical support and practical guidance for the development of more effective tumor immunotherapy methods.
In conclusion, with its diverse selection of target and effector cells and high-precision detection and analysis methods, the ADCC platform of InnoModels Biotechnology has opened up a new path for tumor immunotherapy research. With the deepening of the research, we have reason to believe that this platform will play an even more important role in tumor immunotherapy in the future.