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The technical characteristics of PDX modeling service

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  • Time of issue:2021-01-27 15:35
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(Summary description)10 years of PDX model construction experience, domestic modeling technology, high success rate of modeling; Using the second-generation liquid modeling technology, the efficacy experiment of any scale can be carried out in P1 generation. PDX model quality control level. Quality control of STR and pathogenic microorganism detection in the whole library; The quality of homegrown NPSG mice can be monitored throughout, and the innate immune system strength is better than that of other severely immunodeficient mice, which is more suitable for PDX modeling. During the modeling process, drug resistance screening of the same drug as the patient's chemotherapy can be carried out at the same time, so that the established model is more close to the relapsed tumor. Chemotherapy, targeted and immune checkpoint drugs can be evaluated simultaneously in vitro. The established model can be used to create I-PBMC and I-CD34 + human immune system mouse models.

The technical characteristics of PDX modeling service

(Summary description)10 years of PDX model construction experience, domestic modeling technology, high success rate of modeling;

Using the second-generation liquid modeling technology, the efficacy experiment of any scale can be carried out in P1 generation.

PDX model quality control level. Quality control of STR and pathogenic microorganism detection in the whole library;

The quality of homegrown NPSG mice can be monitored throughout, and the innate immune system strength is better than that of other severely immunodeficient mice, which is more suitable for PDX modeling.

During the modeling process, drug resistance screening of the same drug as the patient's chemotherapy can be carried out at the same time, so that the established model is more close to the relapsed tumor.

Chemotherapy, targeted and immune checkpoint drugs can be evaluated simultaneously in vitro.

The established model can be used to create I-PBMC and I-CD34 + human immune system mouse models.

  • Categories:Company news
  • Author:
  • Origin:
  • Time of issue:2021-01-27 15:35
  • Views:
Information

10 years of PDX model construction experience, domestic modeling technology, high success rate of modeling;

Using the second-generation liquid modeling technology, the efficacy experiment of any scale can be carried out in P1 generation.

PDX model quality control level. Quality control of STR and pathogenic microorganism detection in the whole library;

The quality of homegrown NPSG mice can be monitored throughout, and the innate immune system strength is better than that of other severely immunodeficient mice, which is more suitable for PDX modeling.

During the modeling process, drug resistance screening of the same drug as the patient's chemotherapy can be carried out at the same time, so that the established model is more close to the relapsed tumor.

Chemotherapy, targeted and immune checkpoint drugs can be evaluated simultaneously in vitro.

The established model can be used to create I-PBMC and I-CD34 + human immune system mouse models.

In recent years, many breakthroughs have been made in the field of biomedical research, among which iHuPBMC-T technology is undoubtedly a shining star. As an innovative platform built by InnoModels Biotechnology (Beijing) Co., Ltd, iHuPBMC-T, with its unique technological advantages, shows great potential in optimizing the reconstruction of human peripheral blood single nucleated cell (PBMC) model and immuno-oncology research.
Recently, InnoModels Biotechnology (Beijing) Co., Ltd. has made a major breakthrough in the field of pharmaceutical technology, and successfully obtained a patent entitled “Method and application for the detection of immune system rebuilding ability of PBMC”. This patent not only adds a new footnote to the R&D strength of InnoModels Biotechnology in the field of biomedicine, but also provides a strong technical support for the promotion of drug research and development and the establishment of humanized experimental animal models
With the rapid development of biotechnology, the in-depth study of the immune system has become the key to new drug discovery, disease diagnosis and treatment. InnoModels Bio-technology (Beijing) Co., Ltd. provides strong support for researchers with its profound scientific background and advanced technology platform. Among them, the ELISpot platform of InnoModels Biotechnology has made a name for itself in the field of immunology research with its high sensitivity and multi-functionality
InnoModels' ADCC platform plays a pivotal role in advancing cancer treatment, and its unique technological advantages and innovative concepts have brought about a far-reaching impact on the field of tumor immunotherapy. The following is a detailed introduction of how the platform promotes the advancement of cancer treatment
In the field of tumor immunotherapy, complement-dependent cytotoxicity (CDC), as an important therapeutic mechanism, is gradually showing its great potential and value. In order to explore this mechanism more deeply, with its profound accumulation in the field of oncology and tumor immunopharmacodynamics CRO services, InnoModels Biotechnology (Beijing) Co., Ltd. has launched the CDC in vitro immune-tumor cell co-culture killing experimental platform, which provides researchers with a powerful and precise tool to help innovate cancer treatment
In the vast field of drug discovery and life science research, InnoModels Biotechnology (Beijing) Co., Ltd. is gradually becoming a leader in the industry with its IC50 platform. The platform not only integrates advanced detection technologies, abundant cell resources and strict quality control system, but also provides researchers with efficient and reliable experimental solutions through continuous innovation and optimization.
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