Introducing the PBMC-NK Platform: Revolutionizing Immunotherapy Research! 
 
Are you ready to take your immunotherapy research to the next level? Say hello to the cutting-edge PBMC-NK Platform, a groundbreaking solution designed to accurately assess the true efficacy of investigational drugs. Powered by the innovative PBMC-NK reconstruction model, this platform harnesses the potency of mature human NK cells within a carefully curated cytokine environment, allowing for the robust generation of functional NK cells with superior cytotoxic capabilities. Say goodbye to inaccurate results caused by cell depletion or species-specific differences – the PBMC-NK Platform is here to transform your research landscape.
 
Key Features and Advantages:
●Clinical-Level NK Cell Reconstruction: Achieve extraordinary NK cell concentrations, exceeding 100,000 cells/mL of peripheral blood in mice. Elevate your research with human NK cells that mimic clinical scenarios, ensuring results that mirror real-life drug responses.
●CD16+ Dominance: With over 70% of total NK cells being CD16+ cells, our platform provides a physiologically relevant NK cell composition. This composition ensures that the platform accurately represents the immune response, setting the stage for reliable evaluations.
●Avoid NK Cell Depletion: No more worrying about immune cell exhaustion! Our platform addresses the challenges posed by NK cell depletion, enabling accurate assessments of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC), NK-related immune checkpoints (such as NKG2A), and cytokine effects (like hIL15).
●Seamless Integration with PDX Models: The PBMC-NK Platform plays well with others! Seamlessly integrate our platform with Patient-Derived Xenograft (PDX) models to create a comprehensive and highly predictive research environment.
 
Applications:
The PBMC-NK Platform's versatility knows no bounds:
●Immunotherapy Efficacy Testing: Evaluate investigational drugs with precision, gaining insights into their true potential against a robust NK cell backdrop.
●Immune Checkpoint Studies: Investigate NKG2A-related immunomodulation and its impact on NK cell functionality, opening doors to novel therapeutic avenues.
●Cytokine Effect Analysis: Delve into the power of cytokines like hIL15 in enhancing NK cell responses, offering a deeper understanding of immune modulation.
 
Elevate Your Research with PBMC-NK Platform:
Say farewell to limitations and welcome a new era of immunotherapy research. With clinical-level NK cell reconstruction, a CD16+-dominant composition, and a commitment to accurate assessments, the PBMC-NK Platform is your partner in pioneering discoveries. Join us in shaping the future of immunotherapy – where precision meets potential!
 
Contact us today to unlock the possibilities of the PBMC-NK Platform and propel your research to unprecedented heights. Your breakthrough awaits!  #PBMCNKPlatform #ImmunotherapyInnovation
 
Case examples：
Case 1
Imab362 (CLDN18.2 ADCC monoclonal antibody) exhibited significant pharmacological differences across various models, with the most pronounced efficacy observed in the iHuPBMC humanized mice. Flow cytometry results indicated that the iHuPBMC-NK model mice have the optimal peripheral blood NK (Natural Killer) cell reconstitution, which is a crucial factor influencing the aforementioned pharmacological outcomes.

Case 2
The iHuPBMC-NK platform is capable of reconstituting NK (Natural Killer) cells at a clinical level. Under the influence of long-acting Interleukin-15, the NK cell reconstitution can be enhanced by 7-fold, thereby achieving significant pharmacological effects.

Case 3
High-level reconstitution of NK (Natural Killer) cells enables NK-related immune checkpoint drugs to achieve a significant 50% or higher Tumor Growth Inhibition (TGI) in the A431 humanized mouse model immunosystem established based on the iHuPBMC-NK platform technology.