The tumor tissue microenvironment ( TME ) includes a variety of cancer-associated fibroblasts ( CAFs ), infiltrating immune cells and extracellular matrix (Figure 1 ). Among them, CAF and collagen matrix products are the main components of the desmoplastic cancer matrix and account for a large part of the tumor mass . CAF has pro-inflammatory functions and actively cross-talks with cancer cells. These CAF cells can promote tumor cell growth, angiogenesis and invasion by secreting pro-inflammatory factors, chemokines, growth factors, remodeling of extracellular matrix and other paracrine factors . It can also promote regulatory immune cells in the TME to help tumors establish an immunosuppressive microenvironment .

In addition, CAF is also associated with tumor drug resistance. Its mechanisms affecting drug resistance include ( 1 ) secretion of soluble factors ; ( 2 ) remodeling of the extracellular matrix ( ECM ) ; ( 3 ) reprogramming of the metabolic process of tumor cells ; ( 4 ) induction of epigenetic modifications of tumor cells ; ( 5 ) Delivery of exosomes (Figure 2 )  . Therefore, CAF cells have also received widespread attention in tumor treatment.

Our Solution: High-Stromal Cell Tumor Transplantation Models

Addressing a critical gap in existing mouse models, which fail to simulate the stromal proliferation and histological characteristics found in clinical settings, Model Biotech has constructed high-stromal cell tumor transplantation models. These models, developed through the co-construction of human mesenchymal stem cells (MSCs) and tumor cells, provide more accurate and reliable tools for cancer research.

The High Stromal Tumor Model Platform. Developed by Innomodels Biotech, this platform represents a significant advancement in our understanding and ability to study cancer, particularly focusing on the tumor microenvironment (TME).

At the core of our platform is a deep understanding of the TME, which comprises various elements, including cancer-associated fibroblasts (CAFs), immune cells, and the extracellular matrix. CAFs, known for their pro-inflammatory functions, play a crucial role in tumor growth, angiogenesis, and invasion. They also contribute significantly to tumor drug resistance through various mechanisms, including the secretion of soluble factors and remodeling of the extracellular matrix.

Advantages of Our Platform

Enhanced Tumor Microenvironment Representation: Our models show a significant increase in the richness of the tissue microenvironment, including a higher proportion of collagen fibers and fibroblast structures.

Reduced Immune Cell Infiltration: In tumors inoculated with mixed MSCs, there is a notable reduction in murine immune cell infiltrates, potentially increasing tumor growth stability and speed.

Flexibility and Versatility: Compatible with over 400+ tumor cell line models and PDX models, our platform can construct diverse high-stromal tumor models to meet various research needs.

Bridging Pre-Clinical and Clinical Research

The High Stromal Tumor Model Platform serves as a vital bridge between pre-clinical and clinical research, offering more realistic models that mimic human tumor environments. This leap in technology paves the way for more effective research in CAF-related anti-tumor drugs and other therapeutic strategies.

Join Us in Advancing Cancer Research

At Model Biotech, we are committed to providing innovative solutions to the challenges of cancer research. We invite researchers, clinicians, and institutions to explore the potential of our High Stromal Tumor Model Platform and join us in this exciting journey towards a deeper understanding and more effective treatments for cancer.

Thank you for your attention to this groundbreaking development in cancer research.