New Drug Development Services
Ba/F3 project cell line in vivo pharmacodynamics experimental platform
The Ba/F3 engineered cell line constructed based on the Casper Cas9 technology can provide a pharmacodynamic experimental model for rare drug-resistant mutations in conventional CDX and PDX models for targeted drug research. Chuangmo Biology has established a stable and reliable in vivo pharmacodynamic testing platform for the Ba/F3 engineered cell line using NIG mice, which have stronger tolerance to the Ba/F3 engineered cell line.
• The BA/F3 engineered cell line relies on IL-3 for proliferation and has inserted overexpressed mutation driver genes. It is an ideal experimental system for targeted drug development.
• Based on the NIG mouse's tolerance to immunotoxicity, Chuangmo successfully transplanted the BA/F3 engineered cell line, covering various hotspots, rare, and drug-resistant targets into in vivo models.
• Tumor growth is stable, and the pharmacodynamic reproducibility is strong.
• The pharmacodynamics of various inhibitors are consistent with literature reports.
This platform is suitable for:
• PK/PD experiments to find the optimal in vivo pharmacodynamic dose.
• Screening alternative compounds while assessing pharmacodynamics and toxicity.
• Comparing pharmacodynamics with the previous generation of inhibitors for IND application experiments.
Chuangmo Biology has a rich collection of Ba/F3 engineered cell lines, targeting key genes such as NTRK, RET, MET, EGFR, HER2, and various mutation types. See the Ba/F3 engineered cell line list for details.
Contact Us, the scientific support department of Chuangmo Biology will provide you with detailed information about our experimental platform. We will fully assist you in selecting suitable models for new drug development and offer advice based on our experience in tumor models for your experimental design.