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Introducing the Patent of PBMC Immune System Reconstruction Capability Detection Method and Application by InnoModels Biotechnology

Author:

InnoModels

Release time:

2024-11-25

Recently, InnoModels Biotechnology (Beijing) Co., Ltd. has made a major breakthrough in the field of pharmaceutical technology, and successfully obtained a patent entitled “Method and application for the detection of immune system rebuilding ability of PBMC”. This patent not only adds a new footnote to the R&D strength of InnoModels Biotechnology in the field of biomedicine, but also provides a strong technical support for the promotion of drug research and development and the establishment of humanized experimental animal models.
It is reported that the patent proposes a new method for detecting the immune system rebuilding ability of PBMC (peripheral blood mononuclear cells). The method obtains PBMC samples, determines the proportion a of CD3-positive cells therein and the proportion b of CD45RA-positive cells among the CD3-positive cells, and calculates the proportion of CD45RA-positive cells in the PBMC samples as the reconstruction index by a x b. The method also determines the proportion b of CD45RA-positive cells among the CD3-positive cells as the reconstruction index. The larger the value of the reconstruction index, the higher the immune system reconstruction ability of the PBMC sample, and the Cut-off value of this reconstruction index is 0.2.
This assay has significant advantages. For the first time, it realizes in vitro detection without mice, and can accurately and rapidly determine the reconstruction status of Donor (donor) in mice. This greatly facilitates the selection of Donor and the planning of experimental time, reduces the cost of experiments, and accelerates the drug development process. At the same time, the method also provides strong technical support for the establishment of humanized experimental animal models, which helps to promote the speed and quality of new drug development.

In addition to the assay method, the patent also covers the application of the method in the preparation of screening for drugs used in the treatment of immunodeficiency diseases. By selecting PBMCs with a reconstruction index greater than 0.2 and inoculating them in experimental animals, an experimental animal model is constructed, which can be used to test the efficacy of drug candidates. This application provides new ideas and means for the research and development of drugs for immunodeficiency diseases, and is expected to bring benefits to more patients.
InnoModels Biotechnology (Beijing) Co., Ltd. has been deeply engaged in the field of biomedicine for many years, and has always been committed to promoting the research and development of new drugs and technological innovation. The acquisition of the patent for the detection method and application of PBMC immune system reconstruction ability is another important manifestation of the company's R&D strength and technological innovation ability. In the future, InnoModels Biotechnology will continue to increase its investment in R&D and launch more innovative technologies and products to contribute more to the development of the biopharmaceutical industry.

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Chuangmo Biotechnology (Beijing) Co., Ltd.

Telephone:+8615010000264 +8613810723384
E-mail:cndw@imodels.tech
Address: Building 14, Life Valley, Shuangying West Road, Changping District, Beijing

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