New Drug Development Services
MHC humanized mouse model
Revealing humanized MHC immune competent mouse model
Comprehensively humanized TAP/MHC antigen presentation system, leading a new era in immunology research!
The TAP/MHC antigen presentation system has been fully humanized, elevating antigen presentation to new heights.
Main advantages:
Enhanced antigen presentation:Thismodel excels in effective antigen presentation, ensuring optimal immune response.
High-affinity TCR: Utilizing high-affinity T cell receptors (TCR), strongly binding to antigens, enhancing your research capabilities.
Dual humanization of TAP: The advantage lies in the dual humanization of MHC molecules and TAP molecules. Humanized TAP molecules optimize the recognition of antigen peptides by selectively binding to hydrophobic, basic, and aromatic amino acid sequences.
Mouse TAP: Binds to peptide sequences with hydrophobic C-terminal amino acids.
Human TAP: Preferentially binds to peptide sequences with basic/aromatic/hydrophobic C-terminal amino acids.
●Diverse Antigen Delivery: Unlock the potential to present diverse antigens, including peptides, proteins (RNA, DNA), and more, while accurately screening naturally processed epitopes.
● Robust Epitope Selection: Experience unparalleled epitope screening proficiency, backed by high efficiency and accuracy.
Applications:
● Cancer Vaccines: Validate the accuracy and efficacy of candidate vaccines for tumors, ensuring precision in immunotherapy.
● Viral Epitope Mapping: Uncover the complete landscape of various viruses (HBC/HPV/EBC/CMV/ERV...) with unmatched accuracy.
● Tumor-Specific Markers: Identify and validate tumor-specific markers, offering a cornerstone for both wet-lab and bioinformatics-driven research.
● Novel Antigen Discovery: Identify novel tumor antigens, providing invaluable data for both wet-lab screenings and bioinformatics analyses.
● TCR Screening and Validation: Utilize this model for TCR refinement and validation, improving immune response studies.
Case study.
TAP/MHC Antigen Presentation System Fully Humanized High Antigen Presentation Efficiency Access to High-Affinity TCRs