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InnoModels' CDX Modeling Platform: An Innovative Force for Cancer Research and Drug Development

Author:

InnoModels

Release time:

2024-10-10

In the vast field of cancer research and drug development, InnoModels Biotechnology (Beijing) Co., Ltd. provides powerful support to scientists and doctors with its leading CDX (Cell line-derived xenograft tumor) model platform. The platform not only has diverse tumor cell lines, but also is equipped with a team of experienced experts and advanced experimental technologies, which are dedicated to promoting innovation in biomedical research and clinical treatment.
Unique advantages of CDX model platform
CDX model is a tumor model constructed by transplanting in vitro cultured heterologous (human-derived) tumor cell lines into immunodeficient mice. Compared with other tumor models, CDX model has the advantages of short experimental cycle, high modeling success rate, good reproducibility and relatively low cost. These features make the CDX model an ideal platform for cancer biology research, anti-tumor drug screening and pharmacodynamic evaluation.
Diverse Tumor Cell Lines
InnoModels' CDX model platform has over 400 different tumor cell lines covering a wide range of cancer types and subtypes. This diverse collection of tumor cell lines provides researchers with a wealth of choices, ensuring that they can find the most appropriate cell line for their area of research. Whether it is a common cancer type such as breast cancer, lung cancer or colorectal cancer, InnoModels' CDX modeling platform can provide the appropriate modeling support.

Experienced Team of Experts
The InnoModels Biotechnology team consists of seasoned experts with more than a decade of experience in the field of CDX modeling. From researchers, QC experts to project managers, the team members' shared body of knowledge ensures smooth project execution. They understand the complexities of CDX modeling and can provide valuable insights into its design and implementation. Whether it's designing experiments, solving problems or providing guidance on data interpretation, the experts at InnoModels Biotechnology ensure that the research is on the right track.
Advanced Experimental Technology
InnoModels' CDX modeling platform employs a variety of advanced experimental techniques, including subcutaneous inoculation, bilateral inoculation (lysovirus), and multiple delivery modes (e.g., i.t., i.v., i.p., i.m., p.o., intransal). These technologies allow researchers the flexibility to choose the inoculation and delivery method that best suits their research needs. At the same time, InnoModels Biotechnology also focuses on model quality control to ensure the stability and reliability of the model through a variety of means such as STR (Short Tandem Repeat), Mycoplasma/Chlamydia detection, growth curves, cellular activity assays, and mouse health control.
Innovative applications of Ba/F3 engineered cell lines
In order to further promote targeted drug research, InnoModels Biotechnology has also constructed Ba/F3 engineered cell lines based on Casper Cas9 technology. These cell lines are IL-3-dependent and inserted with overexpression of the mutated Driver gene, making them an ideal experimental system for targeted drug discovery and development. Using NIG mice, which are more tolerant to Ba/F3 engineered cell lines, InnoModels has established a stable and reliable in vivo efficacy test platform. This platform is not only suitable for PK/PD experiments, screening of alternative compounds, and efficacy comparisons, but also provides strong support for IND (New Drug Clinical Trial Application).
Looking to the Future
With the continuous development of cancer treatment and research, CDX model will play a more important role in personalized medicine and targeted therapy. InnoModels Biotechnology will continue to invest in research and development and upgrade its technology to meet the ongoing needs of the research and medical fields. The Company is committed to advancing biomedical research through innovation and providing more effective treatment solutions for cancer patients.
In summary, with its diverse tumor cell lines, experienced team of experts, advanced experimental technologies and innovative application modes, the CDX model platform of InnoModels Biotechnology has demonstrated its strong strength in the field of cancer research and drug development. In the future, the platform will continue to provide scientists and doctors with reliable experimental tools to promote cancer treatment and research to new heights.

PDX in vivo efficacy model of InnoModels Biotechnology

In Vitro Killing Experiment Platform of InnoModels Biotechnology

PDX in vivo efficacy model of InnoModels Biotechnology

In Vitro Killing Experiment Platform of InnoModels Biotechnology

InnoModels Biotechnology (Beijing) Co., Ltd.

TEL: +86 15711355061
E-mail: xuyl@imodels.tech
Address: Building 14, No. 79 West Shuangying Road, Changping District, Beijing

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