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Introduction to the InnoModels Biotechnology Bowel Disease (IBD) Modeling Platform

Author:

InnoModels

Release time:

2024-08-09

Introduction.
Inflammatory Bowel Disease (IBD) is a group of non-specific chronic inflammatory diseases of the colon or gastrointestinal tract of unknown etiology, which was once called "green cancer" because of its easy recurrence and incurable nature.1 The two main types of IBD are Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD consists of two main types: Ulcerative Colitis (UC) and Crohn's Disease (CD), which are characterized by a variety of clinical manifestations and complex treatment. In order to study the pathogenesis of IBD and develop effective therapeutic drugs, the InnoModels Biotechnology platform has constructed a series of animal models of inflammatory bowel disease that highly mimic the characteristics of human diseases.
Platform Overview
The InnoModels Inflammatory Bowel Disease (IBD) platform is a comprehensive platform that integrates the research and development of innovative animal models, production and supply, and experimental services. Relying on advanced gene editing technology and standardized animal breeding management, the platform has established a variety of high-quality IBD animal models, which are widely used in the fields of disease mechanism, drug development and efficacy evaluation.
Introduction of main models
1. DSS-induced mouse IBD model
Dextran Sulfate Sodium Salt (DSS)-induced mouse IBD model is one of the most widely used chemical induced models. By dissolving DSS in drinking water, acute ulcerative enteritis or chronic colitis is induced, destroying the intestinal epithelial cells in mice, ultimately leading to disruption of the integrity of the mucosal barrier. This model is extremely similar to human ulcerative colitis in terms of clinical symptoms and pathological features, making it an ideal model for studying the pathogenesis of IBD and evaluating drug efficacy.
Model characteristics:
- Symptomatic manifestations: the animals showed obvious weight loss, loose stools, blood in the stool, and granulocyte infiltration.
- Pathological features: damage to intestinal epithelial cells, disruption of the integrity of the intestinal mucosal layer, and massive infiltration of inflammatory cells.
- Wide application: It can be used to evaluate the therapeutic effect of various drugs on IBD, such as Cyclosporin A (CsA).
2. TNBS-induced IBD model in rats
A mixture of 2,4,6-trinitrobenzene sulfonic acid (TNBS) and ethanol is commonly used to induce acute ulcerative colitis. Ethanol firstly destroys the intestinal mucosal barrier, and TNBS enters the colonic mucosal tissues and binds to proteins to form alloantigens, activates macrophages, releases a variety of pro-inflammatory factors, and further damages the intestinal mucosal barrier. The model is simple to operate, rapid modeling, and can simulate the acute and chronic dynamic process of ulcerative colitis.

Model characteristics:
- Symptomatic manifestations: weight loss, congestion and edema of the colonic mucosa, thickening of the muscularis propria, multiple ulcers, disappearance of glands and cupped cells, and infiltration of immune cells.
- Pathological features: in addition to the typical pathological manifestations of ulcerative colitis, submucosal hyperplasia of small blood vessels, connective tissue hyperplasia accompanied by fibrosis can also be seen.
- Application: It is suitable for the research of IBD etiology, pathogenesis and development of new drugs for treatment.
Platform Advantages
1. High-quality models
The InnoModels Biotechnology platform ensures the high quality and consistency of IBD models through rigorous gene editing technology and standardized animal husbandry management. These models can highly simulate human disease characteristics, providing a reliable experimental basis for scientific research and drug development.
2. Diversified Services
The platform provides one-stop solutions from model construction, feeding management to experimental services. Customers can choose suitable models for disease mechanism research or drug efficacy evaluation according to their own needs. Meanwhile, the platform also provides professional technical support and data analysis services to ensure the accuracy and reliability of the experimental results.
3. International Standard
All animals on the InnoModels Biotechnology platform are kept in AAALAC-accredited animal facilities and are evaluated for in vivo pharmacodynamics with reference to GLP management standards. This ensures the international recognition and comparability of the experimental results, providing strong support for global scientific collaboration and drug development.
Conclusion
The InnoModels Bioinflammatory Bowel Disease Model Platform is a comprehensive platform that combines innovation, efficiency and standardization. By constructing high-quality IBD animal models, the platform provides strong support for disease mechanism research and drug development. In the future, the platform will play an even more important role in the global biomedical field with the continuous advancement of technology and the expansion of applications.

InnoModels Biotechnology iHuPDX Platform

Functionality of the 3D organoid platform of InnoModels Biotechnology

InnoModels Biotechnology iHuPDX Platform

Functionality of the 3D organoid platform of InnoModels Biotechnology

InnoModels Biotechnology (Beijing) Co., Ltd.

TEL: +86 15711355061
E-mail: xuyl@imodels.tech
Address: Building 14, No. 79 West Shuangying Road, Changping District, Beijing

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