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Introducing the InnoModels Biotechnology IC50 Cell Activity Assay Platform

Author:

InnoModels

Release time:

2024-08-29

Platform Overview
The IC50 Cell Activity Assay Platform of InnoModels Biotechnology (Beijing) Co., Ltd. is a professional service platform integrating years of experience in cell culture and IC50 assay. The platform was co-founded by scientists from Novo Nordisk China R&D Center, Sino-US Champion and the Institute of Immunology of Shanghai Jiao Tong University, and is dedicated to providing high-quality and reliable cell activity assay services to help research and development of oncology and tumor immunotherapy.
Team and Experience
InnoModels Biotechnology has a laboratory team with over 15 years of experience in IC50 and cell culture. The laboratory staff not only possesses profound professional knowledge, but also specializes in IC50 assay and cell culture technology, and is able to provide professional services to customers in the field of cell activity assay. The platform emphasizes data quality and experimental safety. All cells are tested for STR (Short Tandem Repeat Sequence) before use to ensure the accuracy of cell identity, and are regularly tested for mycoplasma and chlamydia in the cell culture solution to ensure the reliability and safety of the experiments.

Cell Resources
The platform has over 400 human-derived tumor cell lines covering a wide range of cancer types and subtypes. This means that researchers can easily select the cell line that suits their research needs, whether for anticancer drug screening or mechanistic studies. This rich cellular resource provides researchers with great convenience and promotes in-depth and extensive research.
Experimental Procedures and Standards
InnoModels' IC50 cell activity assay platform strictly follows a standardized experimental process to ensure that the results of each experiment are credible. The experimental process usually includes steps such as customer ordering online, order/experiment material confirmation, cell processing, MTT stain preparation, MTT incubation (or CCK-8 incubation), DMSO lysis, OD value determination, IC50 calculation and issuance of experiment report. Through this process, the platform can provide customers with high-quality cell activity data to support their research work.
Meaning and application of IC50
IC50 is the concentration of inhibitor when the response is inhibited by half, and is an important measure of antagonist drug potency in pharmacological studies. In the context of apoptosis, IC50 can be understood as the concentration required for a certain concentration of a drug to induce 50% apoptosis in tumor cells. The lower the value, the greater the ability of the drug to induce apoptosis and, inversely, the degree of tolerance of a given cell to the drug.The IC50 value is usually expressed as a molar concentration (mol/L or M) and is determined by a functional assay or a competition binding assay.
In drug screening and efficacy assessment, IC50 is an important indicator of drug cytotoxicity or cellular tolerance to a drug. By calculating the cellular inhibition rate at successive different administered concentrations, a dose response curve can be plotted to estimate the IC50 value. This value is important for evaluating the efficacy and safety of drugs and optimizing drug dosage.
Advanced Technology and Services
In addition to IC50 assays, Transmooker provides a variety of advanced experimental techniques and services, such as CDC (Complement-Dependent Cell Killing Effect Assessment), ADCC (Antibody-Dependent Cell-Mediated Cell Killing Response Measurement), and T-cell-mediated killing assays. These technologies and services are capable of simulating and evaluating the effects of drugs on tumor cells in vitro, providing key insights into immunotherapeutic strategies.
Conclusion
With its abundant cell resources, professional experimental team, standardized experimental process and advanced experimental technology, the InnoModels Biotechnology IC50 cell activity assay platform provides researchers with high-quality and reliable cell activity assay services. The platform is committed to assisting the research and development of tumor and tumor immunotherapy, and promoting the progress and development of medical research. If you have any questions about the platform's services or need further information, please feel free to contact our team.

3D Organoid Platform of InnoModels Biotechnology

Immunogenicity Detection Platform of InnoModels Biotechnology

3D Organoid Platform of InnoModels Biotechnology

Immunogenicity Detection Platform of InnoModels Biotechnology

InnoModels Biotechnology (Beijing) Co., Ltd.

TEL: +86 15711355061
E-mail: xuyl@imodels.tech
Address: Building 14, No. 79 West Shuangying Road, Changping District, Beijing

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